This is one of the continent's oldest cathedrals, the seat of the fourth bishopric of America, although the building that it currently occupies was built in 1922, thus reflecting the eclectic style of architecture. One of its sides houses the Ecclesiastical Museum, with a valuable collection of furniture, paintings and sacred artefacts

Constructed in 1516, this structure is reputed to be Cuba's oldest house one of the oldest in the Americas, although many historians now doubt that claim. Noticeable for its black-slatted balconies, it is one of Santiago's top attractions. Diego Velázquez, the Spanish conquistador who founded the city and was the island's first governor, lived upstairs. At the moment this old house works as Cuban Historical Colonial Environment's Museum, its rooms overflow with period furniture and carved woodwork and encircle­ two lovely courtyards. Inside you'll find period beds, desks, chests, and other furniture. On the first floor is a gold foundry. Memorable are the star-shape Moorish carvings on the wooden windows and balconies, and the original interior patio with its well and rain-collecting tinajón vessel. An adjacent house is filled with antiques intended to convey the French and English decorative and architectural influences—such as the radial stained glass above the courtyard doors—in the late 19th-century.

The cemetery of Santa Ifigenia was founded in February of 1868, to the northwest of the city of Santiago de Cuba, and it was declared National Monument February 7 1937 and ratified as such by the Revolutionary Government May 20 1979. In this cemetery lies some of the personalities’ rest more valiant and illustrate of the independence wars, as well as some outstanding figures of the art and the Cuban culture.  This cemetery is home to the majestic mausoleum of the National Hero from Cuba, José Martí. The structure is true to Martí's wishes (expressed in one of his poems) that he be buried below the flag of Cuba and surrounded by roses. Besides this mausoleum there is a modest vault in a stone brought from Sierra Maestra, in which lies Fidel’s rest. Other highlights include the tombs of Carlos Manuel de Céspedes, the Father of Our Homeland, and those who died in the Moncada Barracks attack and a memorial to Cuban soldiers who have fallen in battle. 

Abel Santamaría Historic Park is compounded by the museum, a library and a monument in the place in which you will find the ruins of the Former Saturnino Lora Civil Hospital. The museum of the enclosure which binds together all these buildings was opened in 1973 on the occasion of the 20th anniversary of the assault to the Moncada Headquarters, and exhibits the history related to the famous assault and the trial of Fidel Castro. The monument opened in 1979 in memory of Abel Santamaría and his colleagues who were tortured and murdered after the failed raising. It has four faces in which there is a sphinx of José Martí, another of Abel Santamaría, six bayonets symbolizing justice; the solitary star and a verse of the National Anthem. The water curtain which seems to support the compound symbolizes the ideals of the young men of the Centenary Generation.