This Spanish-colonial mansion was the birthplace of poet José María Heredia, who, because of his pro-independence writings, is considered Cuba's first national poet. Heredia died in 1839 at age 36 while exiled in Mexico. The house, now just a fraction of its original size, displays period furniture and some of the poet's works and belongings. The home's traditional interior patio is planted with trees and plants—including orange, myrtle, palm, and jasmine—associated with Heredia's verse. A marble plaque on the house's Calle Heredia facade excerpts one of the poet's most famous works, "Niágara".

The Basilica of Our Lady of Charity of El Cobre, the Patron Saint of Cuba, can be found 27 km from the city centre, in a mining town founded in 1830. The Basilica stands on a gentle hill and contains display cases with items such as the medal received by the writer Ernest Hemingway on being awarded the Nobel Prize for Literature in 1954. The story of the Virgin dates from the early 1600s, when three men in a boat first saw her floating on water during a storm; tradition holds that the Virgin saved the men from certain drowning. Records show that the statue was most likely brought from Spain on order of the then-governor of Cuba, but don't play iconoclast with the millions of faithful who take seriously the Virgin's reputed miraculous powers. Our Lady of Charity of El Cobre was crowned by Pope John Paul II in 1998, during his visit to Cuba. Every 8th of September, her feast day, thousands of pilgrims come here to give thanks and beg favours of the blessed virgin.

This is undoubtedly one of the city's most well-known streets. It offers an excellent natural viewing point and is the only stepped street in Cuba. It's part of the Tivoli neighborhood, where 18th-century French-colonial mansions sit side by side with 16th-century structures

In Tivolí you’ll find the famous Padre Pico steps, named for a Santiaguero priest who aided the city’s poor. Fidel Castro once roared fire and brimstone down on the Batista government here, but today you’ll find more pacific chess and domino players who have set up all-hours tables on the steps.