This square dates back to the first half of the 17th century. Its location, just a few metres from the bay, led to it becoming an important trading square over the years. It is said that around the year 1600 the first fountain of the city could be seen at this square. In 1836 it was replaced by a beautiful fountain made of white Carrara marble by Giuseppe Gaggini, under the good auspices of the Villanueva Count. This fountain is called Fuente de los Leones (Lions Fountain). On its paved area stand two noteworthy buildings: the Monastery and Basilica of San Francisco de Asís, which today houses the Museum of Religious Art and a concert hall. It is also where the Lonja del Comercio (Chamber of Commerce) is located, inspired by Spanish Renaissance architecture and topped by a dome on which a sculpture of the god Mercury stands. Among the houses built around the plaza, the house of the Arostegui family, residence of the Captain Generals until the completion of the City Hall at the end of the 18th century, was erected.

The San Francisco de Asís Church and Convent is the current scenario of the richest cultural traditions. This is one of the most extraordinary convent and church complex of the colonial time. The construction of the current set dates from 1738, and it replaced a more modest one completed in 1591. After a restoration in the nineties, the architectural group has harbored, also, a concert hall and the Holy, Sacred and Religious Art museums. The most significant element of the Church is the Tower 42 meters of height, second in altitude at the colonial time. 

The Templete, a small neo-classical style construction, was built in the second half of the 18th Century. It is located in Plaza de Armas. This was the site where the first public mass was celebrated and also the site of the first town council of the nascent town of San Cristóbal de La Habana. The Templete resembles a Doric temple and houses three commemorative canvasses by the famous French painter Juan Bautista Vermey. One of the walls exhibits the plate that declares Old Havana a World Heritage Site.

The Museo Alejandro de Humboldt (Alejandro de Humboldt Museum) is located in a Colonial house in Plaza de San Francisco de Asís Square, in Old Havana, Cuba. Its name comes from the German scientist Alejandro von Humboldt, who is seen as the second person to discover Cuba. This is a scientific museum dedicated to biology and its main objective is to preserve research and promote the historical Humboldt’s legacy. This institution enhances the labor of Cuban and international personalities whose contributions are considered relevant for the development of culture in general terms. It exhibits the historical trajectory of the scientific and botanic data he compiled throughout the island at the beginning of the 19th century, as well as a botanic exhibition which is fundamentally made up of ferns. In this museum there is a perfect copy of a Kritosaurus skeleton found in the desert and donated by the Mexican government, as well as an enormous Pterosaur skeleton, which is around 10 meters length. The House also has a conference room with capacity for 100 persons and a specialized library on German literature.

The Museo del Automóvil (Automobile Museum) is located in an 1892 Neoclassical construction in Old Havana. This museum is divided in two exposition rooms, which share the entire collection composed by 30 promenade cars, two rigid trucks, a funeral carriage, a special vehicle, seven motorcycles, a semaphore, three fuel pumps and two didactic imitations. This museum has a very well preserved and interesting collection of old automobiles, among which are the noteworthy Thunderbird, Pontiac, and Ford T, among others. The oldest vehicle in the collection dates from 1905, and the latest one comes from 1989. Most of them are North American, although some cars were made in Italy, Spain, Germany and Great Britain. It houses automobiles related to specific people and others antiquated vehicles. An example of this is the Cadillac used by Ernesto Che Guevara when living in Havana, the 1930 Fiat from Flor Loynaz, or the 1959 Oldsmobile used by Commander Camilo Cienfuegos.